Brilliant Egyptologist Dr. Julius Kane accidentally unleashes the Egyptian god Set, who banishes the doctor to oblivion and forces his two children to embark on a dangerous journey, bringing them closer to the truth about their family and its links to a secret order that has existed since the time of the pharaohs.

When Apophis, the chaos snake, threatens to plunge the world into eternal darkness, siblings Carter and Sade Kane plan to use an ancient spell to destroy the snake, but first must rely on the murderous ghost of a powerful magician.