Ramona's year in third grade is highlighted by the arrival of Howie's rich Uncle Hobart, a change in her after-school situation, a surprise wedding, a death and a new arrival in the family, and her father's getting a job.

Caught at an awkward in-between age--too little to stay home alone but too big to enjoy playing with pesty Willa Jean at her sitter's house, Ramona just wants to be her mother's little girl forever.

Ramona likes that shes old enough to be counted on, but must everything depend on her? Mrs. Quimby has gone back to work so that Mr. Quimby can return to school, and Ramona is expected to be good for Mrs. Kemp while her parents are away, to be brave enough to ride the school bus by herself, and to put up with being teased by Danny the Yard Ape.